Structure of Spheroidal HDL Particles Revealed by Combined Atomistic and Coarse-Grained Simulations
نویسندگان
چکیده
منابع مشابه
Structure of spheroidal HDL particles revealed by combined atomistic and coarse-grained simulations.
Spheroidal high-density lipoprotein (HDL) particles circulating in the blood are formed through an enzymatic process activated by apoA-I, leading to the esterification of cholesterol, which creates a hydrophobic core of cholesteryl ester molecules in the middle of the discoidal phospholipid bilayer. In this study, we investigated the conformation of apoA-I in model spheroidal HDL (ms-HDL) parti...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2008
ISSN: 0006-3495
DOI: 10.1529/biophysj.107.115857